Publications
2026
- 61.Cell-type targeted CRISPR/Cas9 Clock knockdown in mouse VTA dopamine neurons alter sleep, behavior, and cellular excitability
Ju YH, Zhao JY, Sianati S, Egebjerg C, González OC, Criswell A, Lee CY, Du K, Luff CE, Stralka J, Knapp V, de Lecea L, Kozorovitskiy Y, Kauer JA & Fenno LE
bioRxiv · 2026
- 60.Mechanoluminescent HOF nanotransducers enabled sono-optogenetics in Parkinsonian rats
Wang W, Pyatnitskiy I, Shi Y, Tang KWK, Xie Y, Yu S, Wynn T, Liu X, Hsieh JC, Jeong J, He W, Artman B, Romero Lozano A, Shi X, Sangani A, Fenno LE, Santacruz S, Chen B & Wang H
Advanced Functional Materials · 2026 | Previously listed as a 2025 bioRxiv preprint
- 59.Serotype-dependent differences in AAV cellular transduction rates in the hypothalamus of Arctic ground squirrels
Laughlin BW, Sugiura MH, Tupone D, Fenno LE & Weltzin MM
Journal of Neuroscience Methods · 2026
- 58.Aging-related vulnerability in dopamine-glutamate neurons weakens entorhinal dopamine signaling and underlies novelty discrimination deficits
Tomaio JN, Li Y, Ghazy O, Pavia GH, Fleury S, Bilder A, Nacimba J, Castillo I, Hilaire W, Balogun A, Abhilash L, Kim YS, Ramakrishnan C, Fenno LE, Deisseroth K & Mingote S
Research Square · 2026 | Previously listed as a 2025 bioRxiv preprint
- 57.It's not all DAT: harnessing the potential of organic cation transporter 3 inhibition to selectively attenuate amphetamine reinforcement and dopamine release
Honan LE, Mason B, Owens WA, Shin S, Ju YH, Shi Y, Horton RE, Fenno LE, Collins GT & Daws LC
Neuropsychopharmacology · 2026
- 56.A knock-in Ntsr1-Flp driver enables intersectional and systemic targeting of heterogeneous midbrain dopamine circuits
Garcia F, Villa AP, Wong JT, Wu R, Coriano P, Fenno LE, Leinninger GM & Steele AD
bioRxiv · 2026
2025
- 55.Ultrasound-activated drug release with extracellular vesicles
Shi X, He W, Xu H, Clark L, Zhang HM, Gupta A, Mirle N, Fenno LE, Wang H
bioRxiv · 2025
- 54.Sexually dimorphic mechanisms of VGLUT-mediated protection from dopaminergic neurodegeneration
Buck SA, Rubin SA, Kunkhyen T, Treiber CD, Xue X, Fenno LE, Mabry SJ, Sundar VR, Yang Z, Shah D, Ketchesin KD, Becker-Krail DD, Vasylieva I, Smith MC, Weisel FJ, Wang W, Erickson-Oberg MQ, O'Leary EI, Aravind E, Ramakrishnan C, Kim YS, Wu Y, Quick M, Coleman JA, MacDonald WA, Elbakri R, Olsen AL, Rocha EM, Miller GW, De Miranda BR, Palladino MJ, McCabe BD, Fish KN, Seney ML, Rayport S, Mingote S, Deisseroth K, Hnasko TS, Awatramani R, Watson AM, Waddell S, Cheetham CEJ, Logan RW & Freyberg Z
bioRxiv · 2025
- 53.Salience Signaling and Stimulus Scaling of Ventral Tegmental Area Glutamate Neuron Subtypes
McGovern DJ, Phillips A, Ly A, Prévost ED, Ward L, Siletti K, Kim YS, Fenno LE, Ramakrishnan C, Deisseroth K, Baratta MV, Ford CP & Root DH
J Neuroscience · 2025
- 52.A brain-wide map of descending inputs onto spinal V1 interneurons
Chapman PD, Kulkarni AS, Trevisan AJ, Han K, Hinton JM, Deltuvaite P, Fenno LE, Ramakrishnan C, Patton MH, Schwarz LA, Zakharenko SS, Deisseroth K & Bikoff JB
Neuron · 2025
2024
- 51.Monosynaptic Inputs to Ventral Tegmental Area Glutamate and GABA Co-transmitting Neurons
Prévost ED, Phillips A, Lauridsen K, Enserro G, Rubinstein B, Alas D, McGovern DJ, Ly A, Hotchkiss H, Banks M, McNulty C, Kim YS, Fenno LE, Ramakrishnan C, Deisseroth K & Root DH
J Neuroscience · 2024
- 50.A functional cellular framework for sex and estrous cycle-dependent gene expression and behavior [Erratum]
Knoedler JR, Inoue S, Bayless DW, Yang T, Tantry A, Davis C-H, Leung NY, Parthasarathy S, Wang G, Alvarado M, Rizvi AH, Fenno LE, Ramakrishnan C, Deisseroth K & Shah NM
Cell · 2024
- 49.Neocortical long-range inhibition promotes cortical synchrony and sleep
Ratliff JM, Terral G, Lutzu S, Heiss J, Mota J, Stith B, Vazquez Lechuga A, Ramakrishnan C, Fenno LE, Daigle T, Deisseroth K, Zeng H, Ngai J, Tasic B, Sjulson L, Rudolph S, Kilduff TS & Batista-Brito R
bioRxiv · 2024
- 48.Prefrontal cortical dynorphin peptidergic transmission constrains threat-driven behavioral and network states
Wang H, Flores RJ, Yarur HE, Limoges A, Bravo-Rivera H, Casello SM, Loomba N, Enriquez-Traba J, Arenivar M, Wang Q, Ganley R, Ramakrishnan C, Fenno LE, Kim Y, Deisseroth K, Or G, Dong C, Hoon MA, Tian L & Tejeda HA
Neuron · 2024
- 47.Ribosome-Associated Vesicles promote activity-dependent local translation
Martin-Solana E, Carter SD, Donahue EKF, Ning J, Glausier JR, Preisegger MA, Eisenman L, Joseph PN, Bouchet-Marquis C, Wu K, Mobini CL, Frantz AN, Puig S, Hampton CM, Kabbani N, Jensen GJ, Watkins SC, Deisseroth K, Fenno LE, Gold MS, Wills ZP, Burkewitz K, Das S & Freyberg Z
bioRxiv · 2024
2023
- 46.Ultrasound-induced cascade amplification in a mechanoluminescent nanotransducer for enhanced sono-optogenetic deep brain stimulation
Wang W, Tang KWK, Pyatnitskiy I, Liu X, Shi X, Huo D, Jeong J, Wynn T, Sangani A, Baker A, Hsieh J-C, Romero Lozano A, Artman B, Fenno LE, Buch VP & Wang H
ACS Nano · 2023
- 45.Unique functional responses differentially map onto genetic subtypes of dopamine neurons
Azcorra M, Gaertner Z, Davidson C, He Q, Kim H, Nagappan S, Hayes CK, Ramakrishnan C, Fenno LE, Kim YS, Deisseroth K, Longnecker R, Awatramani R & Dombeck DA
Nature Neuroscience · 2023
2022
- 44.Cell-type-specific population dynamics of diverse reward computations
Sylwestrak EL, Jo Y, Vesuna S, Wang X, Holcomb B, Tien RH, Kim DK, Fenno LE, Ramakrishnan C, Allen WE, Chen R, Shenoy KV, Sussillo D & Deisseroth K
Cell · 2022
- 43.Molecular optimization of rhodopsin-based tools for neuroscience applications
Fenno LE, Levy R & Yizhar O
Rhodopsin: Methods and Protocols (book chapter) · 2022
- 42.A functional cellular framework for sex and estrous cycle-dependent gene expression and behavior
Knoedler JR, Inoue S, Bayless DW, Yang T, Tantry A, Davis C-H, Leung NY, Parthasarathy S, Wang G, Alvarado M, Rizvi AH, Fenno LE, Ramakrishnan C, Deisseroth K & Shah NM
Cell · 2022
2021
- 41.Transcriptional and functional divergence in lateral hypothalamic glutamate neurons projecting to the lateral habenula and ventral tegmental area
Rossi MA, Basiri ML, Liu Y, Hashikawa Y, Hashikawa K, Fenno LE, Kim YS, Ramakrishnan C, Deisseroth K & Stuber GD
Neuron · 2021
- 40.Sox6 expression distinguishes dorsally and ventrally biased dopamine neurons in the substantia nigra with distinctive properties and embryonic origins
Pereira Luppi M, Azcorra M, Caronia-Brown G, Poulin J-F, Gaertner Z, Gatica S, Moreno-Ramos OA, Nouri N, Dubois M, Ma YC, Ramakrishnan C, Fenno LE, Kim YS, Deisseroth K, Cicchetti F, Dombeck DA & Awatramani R
Cell Reports · 2021
- 39.Reciprocal lateral hypothalamic and raphe GABAergic projections promote wakefulness
Gazea M, Furdan S, Sere P, Oesch L, Molnár B, Di Giovanni G, Fenno LE, Ramakrishnan C, Mattis J, Deisseroth K, Dymecki SM, Adamantidis AR & Lőrincz ML
J Neuroscience · 2021
2020
- 38.A molecular calcium integrator reveals a striatal cell type driving aversion
Kim CK, Sanchez MI, Hoerbelt P, Fenno LE, Malenka RC, Deisseroth K & Ting AY
Cell · 2020
- 37.Comprehensive Dual- and Triple-Feature Intersectional Single-Vector Delivery of Diverse Functional Payloads to Cells of Behaving Mammals
Fenno LE, Ramakrishnan C, Kim YS, Evans KE, Lo M, Vesuna S, Inoue M, Cheung KYM, Yuen E, Pichamoorthy N, Hong ASO & Deisseroth K
Neuron · 2020
- 36.Distinct signaling by ventral tegmental area glutamate, GABA, and combinatorial glutamate-GABA neurons in motivated behavior
Root DH, Barker DJ, Estrin DJ, Miranda-Barrientos JA, Liu B, Zhang S, Wang H-L, Vautier F, Ramakrishnan C, Kim YS, Fenno LE, Deisseroth K & Morales M
Cell Reports · 2020
- 35.Genetically targeted chemical assembly of functional materials in living cells, tissues, and animals
Liu J, Kim YS, Richardson CE, Tom A, Ramakrishnan C, Birey F, Katsumata T, Chen S, Wang C, Wang X, Joubert L-M, Jiang Y, Wang H, Fenno LE, Tok JB-H, Pașca SP, Shen K, Bao Z & Deisseroth K
Science · 2020 | News & Views: Neuron-targeted electrical modulation (Otto & Schmidt, Science)
2019
- 34.Sono-optogenetics facilitated by a circulation-delivered rechargeable light source for minimally invasive optogenetics
Wu X, Zhu X, Chong P, Liu J, Andre LN, Ong KS, Brinson K Jr, Mahdi AI, Li J, Fenno LE, Wang H & Hong G
PNAS · 2019
- 33.Excitation of Diverse Classes of Cholecystokinin Interneurons in the Basal Amygdala Facilitates Fear Extinction
Rovira-Esteban L, Gunduz-Cinar O, Bukalo O, Limoges A, Brockway E, Müller K, Fenno LE, Kim YS, Ramakrishnan C, Andrási T, Deisseroth K, Holmes A & Hájos N
ENeuro · 2019
- 32.Mapping Brain-Wide Afferent Inputs of Parvalbumin-Expressing GABAergic Neurons in Barrel Cortex Reveals Local and Long-Range Circuit Motifs
Hafner G, Witte M, Guy J, Subhashini N, Fenno LE, Ramakrishnan C, Kim YS, Deisseroth K, Callaway EM, Oberhuber M, Conzelmann K-K & Staiger JF
Cell Reports · 2019
- 31.A hypothalamus-habenula circuit controls aversion
Lazaridis I, Tzortzi O, Weglage M, Märtin A, Xuan Y, Parent M, Johansson Y, Fuzik J, Fürth D, Fenno LE, Ramakrishnan C, Silberberg G, Deisseroth K, Carlén M & Meletis K
Molecular Psychiatry · 2019
2018
- 30.Structural mechanisms of selectivity and gating in anion channelrhodopsins
Kato HE, Kim YS, Paggi JM, Evans KE, Allen WE, Richardson C, Inoue K, Ito S, Ramakrishnan C, Fenno LE, Yamashita K, Hilger D, Lee SY, Berndt A, Shen K, Kandori H, Dror RO, Kobilka BK & Deisseroth K
Nature · 2018
- 29.Crystal structure of the natural anion-conducting channelrhodopsin GtACR1
Kim YS, Kato HE, Yamashita K, Ito S, Inoue K, Ramakrishnan C, Fenno LE, Evans KE, Paggi JM, Dror RO, Kandori H, Kobilka BK & Deisseroth K
Nature · 2018
- 28.A Guide to Creating and Testing New INTRSECT Constructs
Fenno LE, Mattis J, Ramakrishnan C & Deisseroth K
Current Protocols in Neuroscience · 2018
2017
- 27.The central amygdala controls learning in the lateral amygdala
Yu K, Ahrens S, Zhang X, Schiff H, Ramakrishnan C, Fenno L, Deisseroth K, Zhao F, Luo M-H, Gong L, He M, Zhou P, Paninski L & Li B
Nature Neuroscience · 2017
- 26.Thirst-associated preoptic neurons encode an aversive motivational drive
Allen WE, DeNardo LA, Chen MZ, Liu CD, Loh KM, Fenno LE, Ramakrishnan C, Deisseroth K & Luo L
Science · 2017 | News & Views: Perspective by Gizowski & Bourque (Science)
- 25.Modulation of prefrontal cortex excitation/inhibition balance rescues social behavior in CNTNAP2-deficient mice
Selimbeyoglu A, Kim CK, Inoue M, Lee SY, Hong ASO, Kauvar I, Ramakrishnan C, Fenno LE, Davidson TJ, Wright M & Deisseroth K
Science Translational Medicine · 2017
- 24.Next-generation probes, particles, and proteins for neural interfacing
Rivnay J, Wang H, Fenno L, Deisseroth K & Malliaras GG
Science Advances · 2017
- 23.Distinct Thalamic Reticular Cell Types Differentially Modulate Normal and Pathological Cortical Rhythms
Clemente-Perez A, Ritter Makinson S, Higashikubo B, Brovarney S, Cho FS, Urry A, Holden SS, Wimer M, Dávid C, Fenno LE, Acsády L, Deisseroth K & Paz JT
Cell Reports · 2017
2016
- 22.Midbrain circuits for defensive behaviour
Tovote P, Esposito MS, Botta P, Chaudun F, Fadok JP, Markovic M, Wolff SBE, Ramakrishnan C, Fenno L, Deisseroth K, Herry C, Arber S & Lüthi A
Nature · 2016 | News & Views: On the defensive (Nature Reviews Neuroscience)
2015
- 21.Mapping Anatomy to Behavior in Thy1:18 ChR2-YFP Transgenic Mice Using Optogenetics
Fenno LE, Gunaydin LA & Deisseroth K
Cold Spring Harbor Protocols · 2015
- 20.Chronic Optogenetic Activation Augments Aβ Pathology in a Mouse Model of Alzheimer Disease
Yamamoto K, Tanei Z-I, Hashimoto T, Wakabayashi T, Okuno H, Naka Y, Yizhar O, Fenno LE, Fukayama M, Bito H, Cirrito JR, Holtzman DM, Deisseroth K & Iwatsubo T
Cell Reports · 2015
2014
- 19.Optogenetic neuronal stimulation promotes functional recovery after stroke
Cheng MY, Wang EH, Woodson WJ, Wang S, Sun G, Lee AG, Arac A, Fenno LE, Deisseroth K & Steinberg GK
PNAS · 2014
- 18.Targeting cells with single vectors using multiple-feature Boolean logic
Fenno LE, Mattis J, Ramakrishnan C, Hyun M, Lee SY, He M, Tucciarone J, Selimbeyoglu A, Berndt A, Grosenick L, Zalocusky KA, Bernstein H, Swanson H, Perry C, Diester I, Boyce FM, Bass CE, Neve R, Huang ZJ & Deisseroth K
Nature Methods · 2014
- 17.Natural Neural Projection Dynamics Underlying Social Behavior
Gunaydin LA, Grosenick L, Finkelstein JC, Kauvar IV, Fenno LE, Adhikari A, Lammel S, Mirzabekov JJ, Airan RD, Zalocusky KA, Tye KM, Anikeeva P, Malenka RC & Deisseroth K
Cell · 2014
2013
- 16.Neocortical Circuit Interrogation with Optogenetics
Fenno LE & Deisseroth K
Optical Imaging of Neocortical Dynamics (book chapter) · 2013
- 15.Optogenetic Tools for Control of Neural Activity
Fenno LE & Deisseroth K
Optical Imaging of Neocortical Dynamics (book chapter) · 2013
2012
- 14.Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins
Mattis J, Tye KM, Ferenczi EA, Ramakrishnan C, O'Shea DJ, Prakash R, Gunaydin LA, Hyun M, Fenno LE, Gradinaru V, Yizhar O & Deisseroth K
Nature Methods · 2012
2011
- 13.Neocortical excitation/inhibition balance in information processing and social dysfunction
Yizhar O, Fenno LE, Prigge M, Schneider F, Davidson TJ, O'Shea DJ, Sohal VS, Goshen I, Finkelstein J, Paz JT, Stehfest K, Fudim R, Ramakrishnan C, Huguenard JR, Hegemann P & Deisseroth K
Nature · 2011 | News & Views: When lights take the circuits out (Peça & Feng, Nature)
- 12.The Microbial Opsin Family of Optogenetic Tools
Zhang F, Vierock J, Yizhar O, Fenno LE, Tsunoda S, Kianianmomeni A, Prigge M, Berndt A, Cushman J, Polle J, Magnuson J, Hegemann P & Deisseroth K
Cell · 2011
- 11.SNCA Triplication Parkinson's Patient's iPSC-derived DA Neurons Accumulate α-Synuclein and Are Susceptible to Oxidative Stress
Byers B, Cord B, Nguyen HN, Schule B, Fenno L, Lee PC, Deisseroth K, Langston JW, Reijo Pera R & Palmer TD
PLoS One · 2011
- 10.A new mode of corticothalamic transmission revealed in the Gria4−/− model of absence epilepsy
Paz JT, Bryant AS, Peng K, Fenno L, Yizhar O, Frankel WN, Deisseroth K & Huguenard JR
Nature Neuroscience · 2011
- 9.The Development and Application of Optogenetics
Fenno L, Yizhar O & Deisseroth K
Annual Review of Neuroscience · 2011
- 8.
- 7.Amygdala circuitry mediating reversible and bidirectional control of anxiety
Tye KM, Prakash R, Kim S-Y, Fenno LE, Grosenick L, Zarabi H, Thompson KR, Gradinaru V, Ramakrishnan C & Deisseroth K
Nature · 2011
- 6.Microbial opsins: a family of single-component tools for optical control of neural activity
Yizhar O, Fenno L, Zhang F, Hegemann P & Deisseroth K
Cold Spring Harbor Protocols · 2011
- 5.An implantable optical stimulation delivery system for actuating an excitable biosubstrate
Paralikar K, Cong P, Yizhar O, Fenno LE, Santa W, Nielsen C, Dinsmoor D, Hocken B, Munns GO, Giftakis J, Deisseroth K & Denison T
IEEE Journal of Solid-State Circuits · 2011
2010
- 4.Global and local fMRI signals driven by neurons defined optogenetically by type and wiring
Lee JH, Durand R, Gradinaru V, Zhang F, Goshen I, Kim D-S, Fenno LE, Ramakrishnan C & Deisseroth K
Nature · 2010 | News & Views: fMRI under the spotlight (Leopold, Nature)
2009
- 3.Temporally precise in vivo control of intracellular signalling
Airan RD, Thompson KR, Fenno LE, Bernstein H & Deisseroth K
Nature · 2009 | News & Views: Optical control of reward (Moorman & Aston-Jones, Nature)
2008
- 2.Human embryonic stem cells: emerging technologies and practical applications
Fenno LE, Ptaszek LM & Cowan CA
Current Opinion in Genetics & Development · 2008
- 1.Adult Stem Cells
Fenno LE & Cowan CA
Chemical and Functional Genomic Approaches to Stem Cell Biology and Regenerative Medicine (book chapter) · 2008